American Airlines flight AA 543: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Daily 07:15 Phoenix Sky Harbor (PHX) 4 08:49 Santa Ana (SNA)
AA 543 Non-stop Airbus A321neo (32Q) 1:34 Effective 2026-03-08 through 2026-04-06
Daily 08:44 Phoenix Sky Harbor (PHX) 4 16:12 Raleigh/Durham (RDU) 2
AA 543 Non-stop Airbus A321 (321) 4:28 Effective 2026-05-21 through 2026-08-04
Daily 09:39 Santa Ana (SNA) 11:05 Phoenix Sky Harbor (PHX) 4
AA 543 Non-stop Airbus A321neo (32Q) 1:26 Effective 2026-03-08 through 2026-04-06
Daily 12:07 Phoenix Sky Harbor (PHX) 4 12:34 Santa Ana (SNA)
AA 543 Non-stop Boeing 737 MAX 8 (7M8) 1:27 Effective 2026-01-06 through 2026-02-11
Daily 13:02 Santa Ana (SNA) 15:26 Phoenix Sky Harbor (PHX) 4
AA 543 Non-stop Airbus A321neo (32Q) 1:24 Valid until 2026-01-05
Daily 13:23 Santa Ana (SNA) 15:49 Phoenix Sky Harbor (PHX) 4
AA 543 Non-stop Airbus A321neo (32Q) 1:26 Effective 2026-02-12 through 2026-03-07
Daily 13:24 Santa Ana (SNA) 15:49 Phoenix Sky Harbor (PHX) 4
AA 543 Non-stop Boeing 737 MAX 8 (7M8) 1:25 Effective 2026-01-06 through 2026-02-11
Daily 17:36 Raleigh/Durham (RDU) 2 19:14 Phoenix Sky Harbor (PHX) 4
AA 543 Non-stop Airbus A321 (321) 4:38 Effective 2026-05-21 through 2026-08-04
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This flight number is listed as serving the following routes:
American Airlines flight AA 543: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:

American Airlines AA543
Effective 2026-03-08 through 2026-04-06
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:34, non-stop
Airbus A321neo (32Q)

Direct Flights:

American Airlines AA543
Effective 2026-05-21 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:28, non-stop
Airbus A321 (321)

Direct Flights:

American Airlines AA543
Effective 2026-03-08 through 2026-04-06
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:26, non-stop
Airbus A321neo (32Q)

Direct Flights:

American Airlines AA543
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:27, non-stop
Boeing 737 MAX 8 (7M8)

Direct Flights:

American Airlines AA543
Valid until 2026-01-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:24, non-stop
Airbus A321neo (32Q)

Direct Flights:

American Airlines AA543
Effective 2026-02-12 through 2026-03-07
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:26, non-stop
Airbus A321neo (32Q)

Direct Flights:

American Airlines AA543
Effective 2026-01-06 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:25, non-stop
Boeing 737 MAX 8 (7M8)

Direct Flights:

American Airlines AA543
Effective 2026-05-21 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 4:38, non-stop
Airbus A321 (321)
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This flight number is listed as serving the following routes:
  • Phoenix Sky Harbor (PHX) - Santa Ana (SNA)
  • Raleigh/Durham (RDU) - Phoenix Sky Harbor (PHX)