American Airlines flight AA 5378: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Daily 13:05 Charlotte (CLT) 14:07 Myrtle Beach (MYR)
AA 5378 Non-stop Canadair CRJ 900 (CR9) 1:02 Effective 2026-04-07 through 2026-05-20
Daily 13:10 Chicago O'Hare (ORD) 3 15:44 Knoxville (TYS)
AA 5378 Non-stop Canadair CRJ 700 (CR7) 1:34 Effective 2026-05-21 through 2026-07-01
Daily 13:10 Chicago O'Hare (ORD) 3 15:49 Knoxville (TYS)
AA 5378 Non-stop Canadair CRJ 700 (CR7) 1:39 Effective 2026-07-02 through 2026-08-04
Daily 14:28 Myrtle Beach (MYR) 15:40 Charlotte (CLT)
AA 5378 Non-stop Canadair CRJ 900 (CR9) 1:12 Effective 2026-04-07 through 2026-05-20
Sat 16:39 Ronald Reagan Washington (DCA) 2 17:45 Philadelphia (PHL) F
AA 5378 Non-stop Canadair CRJ 900 (CR9) 1:06 Effective 2026-01-10 through 2026-02-07
Mon-Fri,Sun 16:43 Ronald Reagan Washington (DCA) 2 17:49 Philadelphia (PHL) F
AA 5378 Non-stop Canadair CRJ 900 (CR9) 1:06 Effective 2026-01-07 through 2026-02-11
Tue 16:49 Ronald Reagan Washington (DCA) 2 17:55 Philadelphia (PHL) F
AA 5378 Non-stop Canadair CRJ 900 (CR9) 1:06 Operates only on 2026-01-06
Mon 18:50 Dallas Fort Worth (DFW) 20:21 Baton Rouge (BTR)
AA 5378 Non-stop Canadair CRJ 900 (CR9) 1:31 Operates only on 2026-01-05
Mon,Tue,Thu,Fri,Sun 21:05 Dallas Fort Worth (DFW) 22:37 Baton Rouge (BTR)
AA 5378 Non-stop Canadair CRJ 900 (CR9) 1:32 Valid until 2026-01-04
Daily 21:05 Philadelphia (PHL) F 23:11 Grand Rapids (GRR)
AA 5378 Non-stop Canadair CRJ 700 (CR7) 2:06 Effective from 2026-10-05
Mon,Tue,Thu,Fri,Sun 21:10 Dallas Fort Worth (DFW) E 22:36 Baton Rouge (BTR)
AA 5378 Non-stop Canadair CRJ 700 (CR7) 1:26 Effective 2026-02-12 through 2026-02-19
Tue,Thu,Fri,Sun 21:10 Dallas Fort Worth (DFW) E 22:36 Baton Rouge (BTR)
AA 5378 Non-stop Canadair CRJ 700 (CR7) 1:26 Effective 2026-02-22 through 2026-03-06
Daily 21:10 Dallas Fort Worth (DFW) E 22:39 Baton Rouge (BTR)
AA 5378 Non-stop Canadair CRJ 700 (CR7) 1:29 Effective 2026-03-08 through 2026-04-06
Wed,Fri,Sat 21:30 Dallas Fort Worth (DFW) E 22:56 Baton Rouge (BTR)
AA 5378 Non-stop Canadair CRJ 700 (CR7) 1:26 Effective 2026-02-14 through 2026-02-21
Mon,Wed,Sat 21:30 Dallas Fort Worth (DFW) E 22:56 Baton Rouge (BTR)
AA 5378 Non-stop Canadair CRJ 700 (CR7) 1:26 Effective 2026-02-23 through 2026-03-07
Sat 21:50 Dallas Fort Worth (DFW) 23:13 Baton Rouge (BTR)
AA 5378 Non-stop Canadair CRJ 900 (CR9) 1:23 Valid until 2026-01-03
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This flight number is listed as serving the following routes:


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American Airlines flight AA 5378: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA5378
13:05
Charlotte (CLT)

14:07
Myrtle Beach (MYR)
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:02, non-stop
Canadair CRJ 900 (CR9)
Direct Flights:
American Airlines AA5378
13:10
Chicago O'Hare (ORD) 3

15:44
Knoxville (TYS)
Effective 2026-05-21 through 2026-07-01
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:34, non-stop
Canadair CRJ 700 (CR7)
Direct Flights:
American Airlines AA5378
13:10
Chicago O'Hare (ORD) 3

15:49
Knoxville (TYS)
Effective 2026-07-02 through 2026-08-04
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:39, non-stop
Canadair CRJ 700 (CR7)
Direct Flights:
American Airlines AA5378
14:28
Myrtle Beach (MYR)

15:40
Charlotte (CLT)
Effective 2026-04-07 through 2026-05-20
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:12, non-stop
Canadair CRJ 900 (CR9)
Direct Flights:
American Airlines AA5378
16:39
Ronald Reagan Washington (DCA) 2

17:45
Philadelphia (PHL) F
Effective 2026-01-10 through 2026-02-07
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 1:06, non-stop
Canadair CRJ 900 (CR9)
Direct Flights:
American Airlines AA5378
16:43
Ronald Reagan Washington (DCA) 2

17:49
Philadelphia (PHL) F
Effective 2026-01-07 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 1:06, non-stop
Canadair CRJ 900 (CR9)
Direct Flights:
American Airlines AA5378
16:49
Ronald Reagan Washington (DCA) 2

17:55
Philadelphia (PHL) F
Operates only on 2026-01-06
Mon
-
Tue
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 1:06, non-stop
Canadair CRJ 900 (CR9)
Direct Flights:
American Airlines AA5378
18:50
Dallas Fort Worth (DFW)

20:21
Baton Rouge (BTR)
Operates only on 2026-01-05
Mon
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 1:31, non-stop
Canadair CRJ 900 (CR9)
Direct Flights:
American Airlines AA5378
21:05
Dallas Fort Worth (DFW)

22:37
Baton Rouge (BTR)
Valid until 2026-01-04
Mon
Tue
Wed
-
Thu
Fri
Sat
-
Sun
Duration: 1:32, non-stop
Canadair CRJ 900 (CR9)
Direct Flights:
American Airlines AA5378
21:05
Philadelphia (PHL) F

23:11
Grand Rapids (GRR)
Effective from 2026-10-05
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 2:06, non-stop
Canadair CRJ 700 (CR7)
Direct Flights:
American Airlines AA5378
21:10
Dallas Fort Worth (DFW) E

22:36
Baton Rouge (BTR)
Effective 2026-02-12 through 2026-02-19
Mon
Tue
Wed
-
Thu
Fri
Sat
-
Sun
Duration: 1:26, non-stop
Canadair CRJ 700 (CR7)
Direct Flights:
American Airlines AA5378
21:10
Dallas Fort Worth (DFW) E

22:36
Baton Rouge (BTR)
Effective 2026-02-22 through 2026-03-06
Mon
-
Tue
Wed
-
Thu
Fri
Sat
-
Sun
Duration: 1:26, non-stop
Canadair CRJ 700 (CR7)
Direct Flights:
American Airlines AA5378
21:10
Dallas Fort Worth (DFW) E

22:39
Baton Rouge (BTR)
Effective 2026-03-08 through 2026-04-06
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:29, non-stop
Canadair CRJ 700 (CR7)
Direct Flights:
American Airlines AA5378
21:30
Dallas Fort Worth (DFW) E

22:56
Baton Rouge (BTR)
Effective 2026-02-14 through 2026-02-21
Mon
-
Tue
-
Wed
Thu
-
Fri
Sat
Sun
-
Duration: 1:26, non-stop
Canadair CRJ 700 (CR7)
Direct Flights:
American Airlines AA5378
21:30
Dallas Fort Worth (DFW) E

22:56
Baton Rouge (BTR)
Effective 2026-02-23 through 2026-03-07
Mon
Tue
-
Wed
Thu
-
Fri
-
Sat
Sun
-
Duration: 1:26, non-stop
Canadair CRJ 700 (CR7)
Direct Flights:
American Airlines AA5378
21:50
Dallas Fort Worth (DFW)

23:13
Baton Rouge (BTR)
Valid until 2026-01-03
Mon
-
Tue
-
Wed
-
Thu
-
Fri
-
Sat
Sun
-
Duration: 1:23, non-stop
Canadair CRJ 900 (CR9)
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This flight number is listed as serving the following routes:
  • Charlotte (CLT) - Myrtle Beach (MYR)
  • Chicago O'Hare (ORD) - Knoxville (TYS)
  • Dallas Fort Worth (DFW) - Baton Rouge (BTR)
  • Philadelphia (PHL) - Grand Rapids (GRR)
  • Ronald Reagan Washington (DCA) - Philadelphia (PHL)
All American Airlines flights
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