American Airlines flight AA 4643: Multiple routes

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FLIGHT SCHEDULE
Direct Flights:
Fri 11:00 Ronald Reagan Washington (DCA) 2 12:36 Boston Logan (BOS) B
AA 4643 Non-stop Embraer EMB 175 (E75) 1:36 Operates only on 2025-07-04
Mon 12:00 Ronald Reagan Washington (DCA) 2 13:37 Dayton (DAY)
AA 4643 Non-stop Embraer EMB 175 (E75) 1:37 Operates only on 2025-05-05
Mon-Fri,Sun 13:44 Ronald Reagan Washington (DCA) 2 15:24 Boston Logan (BOS) B
AA 4643 Non-stop Embraer EMB 175 (E75) 1:40 Effective 2025-06-05 through 2025-07-03
Mon 14:07 Dayton (DAY) 15:36 Ronald Reagan Washington (DCA) 2
AA 4643 Non-stop Embraer EMB 175 (E75) 1:29 Operates only on 2025-05-05
Mon-Fri,Sun 15:03 Ronald Reagan Washington (DCA) 2 17:51 Fort Myers (RSW)
AA 4643 Non-stop Embraer EMB 175 (E75) 2:48 Effective 2025-07-06 through 2025-08-05
Mon-Fri,Sun 15:54 Boston Logan (BOS) B 17:46 Ronald Reagan Washington (DCA) 2
AA 4643 Non-stop Embraer EMB 175 (E75) 1:52 Effective 2025-06-05 through 2025-07-03
Daily 16:04 Indianapolis (IND) 17:55 Philadelphia (PHL)
AA 4643 Non-stop Embraer EMB 175 (E75) 1:51 Effective from 2026-02-12
Daily 16:05 Indianapolis (IND) 17:55 Philadelphia (PHL)
AA 4643 Non-stop Embraer EMB 175 (E75) 1:50 Effective 2025-12-18 through 2026-02-11
Mon-Fri,Sun 18:27 Fort Myers (RSW) 20:59 Ronald Reagan Washington (DCA) 2
AA 4643 Non-stop Embraer EMB 175 (E75) 2:32 Effective 2025-07-06 through 2025-08-05
Daily 22:00 Ronald Reagan Washington (DCA) 2 23:20 Syracuse (SYR)
AA 4643 Non-stop Embraer EMB 175 (E75) 1:20 Effective 2025-08-06 through 2025-09-02
Daily 22:00 Ronald Reagan Washington (DCA) 2 23:26 Syracuse (SYR)
AA 4643 Non-stop Embraer EMB 175 (E75) 1:26 Effective 2025-10-06 through 2025-10-25
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This flight number is listed as serving the following routes:


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American Airlines flight AA 4643: Multiple routes
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Select flight date:
FLIGHT SCHEDULE
Direct Flights:
American Airlines AA4643
11:00
Ronald Reagan Washington (DCA) 2

12:36
Boston Logan (BOS) B
Operates only on 2025-07-04
Mon
-
Tue
-
Wed
-
Thu
-
Fri
Sat
-
Sun
-
Duration: 1:36, non-stop
Embraer EMB 175 (E75)
American Airlines AA4643
12:00
Ronald Reagan Washington (DCA) 2

13:37
Dayton (DAY)
Operates only on 2025-05-05
Mon
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 1:37, non-stop
Embraer EMB 175 (E75)
American Airlines AA4643
13:44
Ronald Reagan Washington (DCA) 2

15:24
Boston Logan (BOS) B
Effective 2025-06-05 through 2025-07-03
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 1:40, non-stop
Embraer EMB 175 (E75)
American Airlines AA4643
14:07
Dayton (DAY)

15:36
Ronald Reagan Washington (DCA) 2
Operates only on 2025-05-05
Mon
Tue
-
Wed
-
Thu
-
Fri
-
Sat
-
Sun
-
Duration: 1:29, non-stop
Embraer EMB 175 (E75)
American Airlines AA4643
15:03
Ronald Reagan Washington (DCA) 2

17:51
Fort Myers (RSW)
Effective 2025-07-06 through 2025-08-05
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 2:48, non-stop
Embraer EMB 175 (E75)
American Airlines AA4643
15:54
Boston Logan (BOS) B

17:46
Ronald Reagan Washington (DCA) 2
Effective 2025-06-05 through 2025-07-03
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 1:52, non-stop
Embraer EMB 175 (E75)
American Airlines AA4643
16:04
Indianapolis (IND)

17:55
Philadelphia (PHL)
Effective from 2026-02-12
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:51, non-stop
Embraer EMB 175 (E75)
American Airlines AA4643
16:05
Indianapolis (IND)

17:55
Philadelphia (PHL)
Effective 2025-12-18 through 2026-02-11
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:50, non-stop
Embraer EMB 175 (E75)
American Airlines AA4643
18:27
Fort Myers (RSW)

20:59
Ronald Reagan Washington (DCA) 2
Effective 2025-07-06 through 2025-08-05
Mon
Tue
Wed
Thu
Fri
Sat
-
Sun
Duration: 2:32, non-stop
Embraer EMB 175 (E75)
American Airlines AA4643
22:00
Ronald Reagan Washington (DCA) 2

23:20
Syracuse (SYR)
Effective 2025-08-06 through 2025-09-02
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:20, non-stop
Embraer EMB 175 (E75)
American Airlines AA4643
22:00
Ronald Reagan Washington (DCA) 2

23:26
Syracuse (SYR)
Effective 2025-10-06 through 2025-10-25
Mon
Tue
Wed
Thu
Fri
Sat
Sun
Duration: 1:26, non-stop
Embraer EMB 175 (E75)
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This flight number is listed as serving the following routes:
  • Boston Logan (BOS) - Ronald Reagan Washington (DCA)
  • Indianapolis (IND) - Philadelphia (PHL)
  • Ronald Reagan Washington (DCA) - Dayton (DAY)
  • Ronald Reagan Washington (DCA) - Fort Myers (RSW)
  • Ronald Reagan Washington (DCA) - Syracuse (SYR)
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